Hydrochloric Acid → HCID 68227296, compound

HRID 2368808Notes

Reaction equation

HRID 2368808 reaction equation
[F:1][C:2]([F:36])([F:35])[C@@H:3]([C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:33][CH2:32][C:22]3([CH2:31][CH2:30][C:25]4(OCC[O:26]4)[CH2:24][CH2:23]3)[C:21]2=[O:34])=[CH:16][CH:15]=1)[O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1.Cl>C1COCC1>[F:36][C:2]([F:1])([F:35])[C@@H:3]([C:14]1[CH:15]=[CH:16][C:17]([N:20]2[CH2:33][CH2:32][C:22]3([CH2:31][CH2:30][C:25](=[O:26])[CH2:24][CH2:23]3)[C:21]2=[O:34])=[CH:18][CH:19]=1)[O:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][CH3:13])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68227587HCID 68227587, compound

Product 1

HCID 68227296HCID 68227296, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared in analogy to example 1, step 5 from 10-{4-[(R)-2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-ethyl]-phenyl}-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (4.91 g) by treatment with 2 M HCl (58.3 ml) in THF (68.2 ml) as a white solid. (3.5 g).

Sources & evidence

ORD record
ord-b74cc24a2c14424bb5732972b261db97
Source dataset
uspto-grants-2014_04
Patent number
US08703807B2

Reaction notes

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