Triethylamine → HCID 66701951, compound

HRID 2369204Notes

Reaction equation

HRID 2369204 reaction equation
Cl.[NH2:2][C@H:3]1[C:12]([CH2:15][CH3:16])([CH2:13][CH3:14])[C:11]2[CH:10]=[C:9]([OH:17])[CH:8]=[CH:7][C:6]=2[CH2:5][C@@H:4]1[O:18][CH3:19].[CH3:20][O:21][C:22](=[O:34])[C@H:23]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)[CH2:24][CH:25]=O.C(N(CC)CC)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl.CCOC(C)=O>[CH3:20][O:21][C:22](=[O:34])[C@H:23]([CH2:27][CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1)[CH2:24][CH2:25][NH:2][C@@H:3]1[C@@H:4]([O:18][CH3:19])[CH2:5][C:6]2[C:11](=[CH:10][C:9]([OH:17])=[CH:8][CH:7]=2)[C:12]1([CH2:15][CH3:16])[CH2:13][CH3:14]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 5049666Sodium triacetoxyborohydride2×HCID 66674947HCID 66674947, compoundHCID 86631187HCID 86631187, compound2×

Product 1

HCID 66701951HCID 66701951, compoundYield 121.8%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

(6S,7S)-7-Amino-8,8-diethyl-6-methoxy-5,6,7,8-tetrahydro-naphthalen-2-ol hydrochloride salt (100 mg, 0.35 mmol), (R)-2-cyclohexylmethyl-4-oxo-butyric acid methyl ester (90 mg, 0.42 mmol) and triethylamine (35 mg, 0.035 mmol) were dissolved in dichloromethane (2.0 mL) and stirred at room temperature for 30 min. Sodium triacetoxyborohydride (1.03 g, 4.85 mmol) was added and the reaction was monitored by HPLC. After 3 h, additional (R)-2-cyclohexylmethyl-4-oxo-butyric acid methyl ester (20 mg, 0.1 mmol) and sodium triacetoxyborohydride (30 mg, 0.14 mmol) were added. Thirty minutes after the last addition, EtOAc (15 mL) was added and the mixture was washed with 5% aqueous sodium carbonate (2×5 mL) and saturated sodium chloride (5 mL). The organic layer was dried with Na2SO4) and concentrated to give the title compound (190 mg). (m/z): [M+H]+ calcd for C27H43NO4, 446.33; found, 446.6.

Workup

  1. waitAfter 3 h
  2. additionwas added
  3. washthe mixture was washed with 5% aqueous sodium carbonate (2×5 mL) and saturated sodium chloride (5 mL)
  4. dry with materialThe organic layer was dried with Na2SO4) and
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-b0d6900318a6404fb3c5efd96a0647ad
Source dataset
uspto-grants-2014_04
Patent number
US08703791B2

Reaction notes

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