Trifluoroacetic acid → HCID 86647139, compound

HRID 2369803Notes

Reaction equation

HRID 2369803 reaction equation
C([O:5][C:6](=[O:21])[CH2:7][CH2:8][N:9]([CH2:18][CH2:19][NH2:20])[CH2:10]C(OC(C)(C)C)=O)(C)(C)C.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>C1COCC1>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[NH2:20][CH2:19][CH2:18][N:9]([CH3:10])[CH2:8][CH2:7][C:6]([OH:21])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86647138HCID 86647138, compound

Product 1

HCID 86647139HCID 86647139, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-(Boc-aminoethyl-methyl-amino)-propionic acid tert-butyl ester (630 mg, 2.1 mmol) was treated with trifluoroacetic acid (6 mL) for 2 hours. 3-(Aminoethyl-methyl-amino)-propionic acid trifluoroacetic acid salt was isolated by recrystallisation from THF to give a white powder, 974 mg (quantitative).

Sources & evidence

ORD record
ord-859adf4764d840e8856dd7d735fa35cc
Source dataset
uspto-grants-2014_04
Patent number
US08710000B2

Reaction notes

Loading…