Methane → HCID 131717192, compound

HRID 2371955Notes

Reaction equation

HRID 2371955 reaction equation
[CH3:1][C:2]1[N:3]([C:8]2[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[C:16]([N:18]([CH3:20])[OH:19])=[O:17])=[CH:10][CH:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24].C>CO>[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24].[CH3:1][C:2]1[N:3]([C:8]2[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[C:16]([N:18]([CH3:20])[OH:19])=[O:17])=[CH:10][CH:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 297MethaneHCID 6503Tris(hydroxymethyl)aminomethaneHCID 6439321131817-86-2

Product 1

HCID 131717192HCID 131717192, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]-N-methyl-2-propenohydroxamic acid (1.85 g) is added to a solution of 0.85 g of tromethamine in 150 ml of methanol. The resulting solution is treated with charcoal, filtered and evaporated to dryness. The residue is crystallized from ether to obtain (E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]-N-methyl-2-propenohydroxamic acid tromethamine salt, m.p. 134°-136°.

Workup

  1. filtrationfiltered
  2. customevaporated to dryness
  3. customThe residue is crystallized from ether

Sources & evidence

ORD record
ord-c40514f2e6f6453a99fcc6a2dca970c0
Source dataset
uspto-grants-1992_03
Patent number
US05096919

Reaction notes

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