Potassium Carbonate → HCID 86657060, compound

HRID 237270Notes

Reaction equation

HRID 237270 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:11][CH:10]([O:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[O:20][CH:21]2[CH2:29][C:28]3[C:23](=[CH:24][C:25](F)=[CH:26][CH:27]=3)[C:22]2=O)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:32][OH:33].Cl.C([O-])([O-])=O.[K+].[K+]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:11][CH:10]([O:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[O:20][CH:21]2[CH2:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[C:22]2=[N:32][OH:33])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 67346581HCID 67346581, compound

Product 1

HCID 86657060HCID 86657060, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

The title compound of Step A was dissolved into MeOH (2 mL), then NH2OH HCl (1 mmol) and K2CO3 (2 mmol) were added. The mixture was heated at 100° C. using a microwave reactor for 1 h. The mixture was cooled to rt and purified by PTLC providing the title compound (120 mg).

Workup

  1. customfor 1 h
  2. temperatureThe mixture was cooled to rt
  3. custompurified by PTLC

Sources & evidence

ORD record
ord-bbe6be8281f644f18a4cc4d24bf0bc43
Source dataset
uspto-grants-2014_02
Patent number
US08642583B2

Reaction notes

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