Diethyl (ethoxymethylene)malonate → HCID 9980359, compound

HRID 2372848Notes

Reaction equation

HRID 2372848 reaction equation
C([O:5][C:6]([C:8]1[CH:27]=[CH:26][CH:25]=[CH:24][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18](=[NH:23])[CH2:19][CH2:20][CH2:21][CH3:22])=[CH:12][CH:11]=1)=[O:7])(C)(C)C.C([O:30][CH:31]=[C:32]([C:38](OCC)=O)[C:33]([O:35][CH2:36][CH3:37])=[O:34])C>FC(F)(F)C(O)=O>[CH2:19]([C:18]1[N:17]([CH2:16][C:13]2[CH:12]=[CH:11][C:10]([C:9]3[CH:24]=[CH:25][CH:26]=[CH:27][C:8]=3[C:6]([OH:5])=[O:7])=[CH:15][CH:14]=2)[C:31](=[O:30])[C:32]([C:33]([O:35][CH2:36][CH3:37])=[O:34])=[CH:38][N:23]=1)[CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 178446843HCID 178446843, compound

Product 1

HCID 9980359HCID 9980359, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The title compound is prepared form N-(2'-t-butoxycarbonylbiphen-4-yl)methylvaleramidine and diethyl ethoxymethylenemalonate (Aldrich) similarly to that in Example 7. The t-butyl ester is hydrolyzed in neat trifluoroacetic acid to give the title compound.

Sources & evidence

ORD record
ord-94cefef9de104fb0b10b7439247abbc5
Source dataset
uspto-grants-1992_03
Patent number
US05100897

Reaction notes

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