反应详情

A mixture of 3-chlorobenzaldehyde (2 g), ethyl acetoacetate (1.94 g), AcOH (0.23 ml), piperidine (0.23 ml) in cyclohexane (40 ml) was refluxed azeotropically for 2 hours. After cooling, the reaction mixture was diluted with EtOAc. The organic layer was washed with water, saturated aqueous NaHCO3, brine, dried over anhydrous MgSO4 and concentrated in vacuo to give ethyl 2-acetyl-3-(3-chlorophenyl)acrylate (4.19 g) as a yellow oil.

1. temperaturewas refluxed azeotropically for 2 hours
2. temperatureAfter cooling
3. washThe organic layer was washed with water, saturated aqueous NaHCO3, brine
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated in vacuo