Potassium Carbonate → HCID 56946587, compound

HRID 2373370Notes

Reaction equation

HRID 2373370 reaction equation
C([O-])(O)=O.[Na+].C([O-])([O-])=O.[K+].[K+].[Cl:12][C:13]1[CH:14]=[CH:15][C:16]2[C:22](=O)[C:21](=[CH:24]N(C)C)[CH2:20][C:19](=[O:28])[NH:18][C:17]=2[CH:29]=1.[NH:30]([C:34]1[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=1)[C:31]([NH2:33])=[NH:32]>CCO.CN(C=O)C>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]2[C:22]3[N:32]=[C:31]([NH:30][C:34]4[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=4)[N:33]=[CH:24][C:21]=3[CH2:20][C:19](=[O:28])[NH:18][C:17]=2[CH:29]=1

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 516892Sodium BicarbonateHCID 669348778-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 178512548HCID 178512548, compound

Product 1

HCID 56946587HCID 56946587, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

In a manner similar to method I (DMF and NaHCO3 were used in place of EtOH and K2CO3), 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and 4-guanidinobenzoic acid were converted to I-3 (68%): HRMS Calcd. for C19H13ClN4O3: 381.0754, Found 381.0721.

Sources & evidence

ORD record
ord-50b491e91ee74ff4abfd8f05cb84e190
Source dataset
uspto-grants-2008_12
Patent number
US07459448B2

Reaction notes

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