反应详情

温度

85 °C

Sodium hydrogen carbonate was added to a solution of 2-Amino-4-(2,4-dimethylphenyl)-6-mercapto-pyrimidine-5-carbaldehyde in DMF and the suspension stirred. C-bromo-N-cyclopropyl-methane sulphonamide was added, and the mixture heated, ˜85° C., for ˜3 hrs. The resulting suspension was allowed to cool and ethyl acetate added, the mixture was washed with water and saturated aqueous sodium chloride solution. The solution was dried over anhydrous sodium sulphate and concentrated to a pale yellow solid. The crude solid was purified by column chromatography on silica eluting with mixtures of ethyl acetate and hexane.

1. temperatureto cool
2. washthe mixture was washed with water and saturated aqueous sodium chloride solution
3. dry with materialThe solution was dried over anhydrous sodium sulphate
4. concentrationconcentrated to a pale yellow solid
5. customThe crude solid was purified by column chromatography on silica eluting with mixtures of ethyl acetate and hexane