反应详情

To a solution of 2-amino-4-chloro-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (1 equiv.) and benzo[1,3]dioxol-5-yl-acetonitrile (1 mole eq.) in DMF at room temperature, sodium hydride (1.1 mole eq., 60% in mineral oil) was added. The mixture was stirred at this temperature overnight under argon. After that, it was diluted with brine and extracted with ethyl acetate. The combined organic portions were washed with brine and water and dried with sodium sulphate. After filtration and evaporation of the solvent, brown solids were obtained which were purified either by preparative TLC or preparative HPLC.

1. extractionextracted with ethyl acetate
2. washThe combined organic portions were washed with brine and water
3. dry with materialdried with sodium sulphate
4. filtrationAfter filtration and evaporation of the solvent
5. custombrown solids were obtained which
6. customwere purified either by preparative TLC or preparative HPLC