Ethanolamine → HCID 87694169, compound

HRID 2374126Notes

Reaction equation

HRID 2374126 reaction equation
[F:1][C:2]([F:8])([F:7])[C:3](OC)=[O:4].[CH2:9]([CH2:11][NH2:12])[OH:10].C1C=C2C(C(O)(O)C(=O)C2=CC=1)=O>>[F:1][C:2]([F:8])([F:7])[C:3]([NH2:12])=[O:4].[CH2:9]([CH2:11][NH2:12])[OH:10]

Participants

4

Reactant 3

HCID 700EthanolamineHCID 9893Methyl trifluoroacetateHCID 10236Ninhydrin

Product 1

HCID 87694169HCID 87694169, compound

Procedure

In a round-bottom flask, methyl trifluoroacetate (10.5 g, 81.9 mmol) was added to neat ethanolamine (4.0 g, 66 mmol) at room temperature with continuous stirring. Reaction completion was determined by the absence of ninhydrin activity. After 2 h, the reaction was concentrated by rotary evaporation and purified by distillation (11 mm Hg, b.p. 127° C.), yielding a colorless oil, 9.5 g, 93%.

Workup

  1. customReaction completion
  2. concentrationthe reaction was concentrated by rotary evaporation
  3. distillationpurified by distillation (11 mm Hg, b.p. 127° C.)
  4. customyielding a colorless oil, 9.5 g, 93%

Sources & evidence

ORD record
ord-b22d430e38934cc99c0add9e46c9c189
Source dataset
uspto-grants-2008_12
Patent number
US07462451B2

Reaction notes

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