反应详情

A mixture of 9-allyl-6-pentyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one (0.10 g, 0.35 mmol) and morpholine (0.2 mL, 2.0 mmol) in THF (3 mL) was degassed for 5 min using N2 and tetrakis(triphenylphosphine)palladium(0) (0.10 g, 0.086 mmol) was added to the mixture. After being stirred at room temperature overnight, the reaction mixture was mixed with 2 M HCl aqueous solution and DCM. The organic layer was separated, dried over Na2SO4 and concentrated. The residue was purified using preparative LCMS to provide the product as a white powder (0.030 g, 35%). LCMS calculated for C10H14N7O (M+H): 248.0; found: 248.0.

1. customwas degassed for 5 min
2. additionwas added to the mixture
3. customThe organic layer was separated
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customThe residue was purified