反应详情

Oxalyl chloride (5.86 ml) was added by portions to a solution of 2-methyl-1,3-dioxo-5-isoindolinecarboxylic acid (9.2 g) obtained in Reference Example 229. and dimethylformamide (catalytic amount) in tetrahydrofuran (100 ml) at room temperature. After stirred at room temperature for 1 hour, the solvent was evaporated under reduced pressure. The resulting residue was filtered, washed with diethyl ether and dried under reduced pressure to give the title compound as a white solid.

1. customobtained in Reference Example 229
2. customat room temperature
3. customthe solvent was evaporated under reduced pressure
4. filtrationThe resulting residue was filtered
5. washwashed with diethyl ether
6. customdried under reduced pressure