Ethyl Bromide → HCID 69277513, compound

HRID 2375400Notes

Reaction equation

HRID 2375400 reaction equation
[C:1]([C:4]1[C:5]([C:20](=[O:22])[CH3:21])=[C:6]([CH3:19])[N:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][C:11]=2[O:17][CH3:18])[C:8]=1[CH3:9])(=[O:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].Br[CH2:30][CH3:31]>>[C:20]([C:5]1[C:4]([C:1](=[O:3])[CH3:2])=[C:8]([CH3:9])[N:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:30][CH3:31])=[CH:12][C:11]=2[O:17][CH3:18])[C:6]=1[CH3:19])(=[O:22])[CH3:21]

Participants

4

Reactant 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 69275281HCID 69275281, compound

Product 1

HCID 69277513HCID 69277513, compound

Procedure

Utilizing the general procedure outlined in Example 65, 1-[4-acetyl-1-(4-hydroxy-2-methoxy-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-ethanone (70 mg, 2.3 mmol) reacted with bromoethane (300 μL, excess), in the presence of K2CO3 (50 mg), to afford 1-[4-acetyl-1-(4-ethoxy-2-methoxy-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-ethanone: MS (ESI) 330 (M+H)+.

Sources & evidence

ORD record
ord-de3a5bfdd9fc42fda0fd3b8ff85920d9
Source dataset
uspto-grants-2008_12
Patent number
US07465730B2

Reaction notes

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