Hydrogen Peroxide → 649551-06-4

HRID 2376207Notes

Reaction equation

HRID 2376207 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[N:12]=[C:11]([CH2:22][C@@H:23]([C:39]3[CH:40]=[C:41]([CH3:45])[CH:42]=[CH:43][CH:44]=3)[C:24](N3[C@H]4C5C=CC=CC=5C[C@H]4OC3=O)=[O:25])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH:46]O.O[Li].O>C1COCC1.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=3)[N:12]=[C:11]([CH2:22][C@@H:23]([C:39]3[CH:40]=[C:41]([CH3:45])[CH:42]=[CH:43][CH:44]=3)[C:24]([OH:46])=[O:25])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 168937Lithium hydroxide, monohydrateHCID 58630661HCID 58630661, compound

Product 1

HCID 11488979649551-06-4Yield 81.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of (2S,3aS,8aR)-3-{3-[5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionyl}-3,3a,8,8a-tetrahydro-indeno[1,2-d]oxazol-2-one (20.7 g, 0.0323 mol) in THF (230 mL) and H2O (45 mL) at 0° C. was added 30% H2O2 (15.0 mL, 0.147 mol) followed by LiOH hydrate (2.75 g, 0.0655 mol) in H2O (15 mL). The reaction mixture was allowed to warm to rt and was stirred for 90 min. The mixture was cooled to 0° C. and then quenched with 1.5 N Na2SO3 (20 mL) maintaining pH 9-10. The mixture was concentrated to ¼ volume, then treated with H2O (200 mL) and acidified to pH 1-2 using 3 N HCl. The aqueous layer was washed with EtOAc (3×100 mL). The combined organic layers were dried with Na2SO4, filtered and concentrated to ¼ volume. Solid crystals that developed overnight were filtered and washed with cold 1:1 hexane/EtOAc. The chiral auxiliary was recovered in 66% yield (3.72 g). The filtrate was purified by flash chromatography (7:3 hexane/EtOAc with 0.3% MeOH) to afford 12.7 g (81.5%) of (S)-3-[5-(3,4-dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid as orange oil. HPLC: Rt=10.44 (Method E). MS (ES+): mass calculated for C26H22Cl2N3, 481.37; m/z found 503.2 [M+Na]+. 1H NMR (400 MHz, CDCl3): 7.12-7.31 (m, 9H), 6.90 (dd, J=6.3, 2.0 Hz, 1H), 6.86 (d, J=9.1 Hz, 2H), 6.21 (s, 1H), 4.07-4.15 (m, 1H), 3.82 (s, 3H), 3.53 (dd, J=9.3, 5.3 Hz, 1H), 3.10 (dd, J=9.1, 5.8 Hz, 1H), 2.35 (s, 3H).

Workup

  1. temperatureThe mixture was cooled to 0° C.
  2. customquenched with 1.5 N Na2SO3 (20 mL)
  3. temperaturemaintaining pH 9-10
  4. concentrationThe mixture was concentrated
  5. additiontreated with H2O (200 mL)
  6. washThe aqueous layer was washed with EtOAc (3×100 mL)
  7. dry with materialThe combined organic layers were dried with Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated
  10. waitSolid crystals that developed overnight
  11. filtrationwere filtered
  12. washwashed with cold 1:1 hexane/EtOAc
  13. customThe chiral auxiliary was recovered in 66% yield (3.72 g)
  14. customThe filtrate was purified by flash chromatography (7:3 hexane/EtOAc with 0.3% MeOH)

Sources & evidence

ORD record
ord-525c99dbe1e940d59c23c2b28c7ee10a
Source dataset
uspto-grants-2008_12
Patent number
US07465808B2

Reaction notes

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