Water → HCID 23688043, compound

HRID 2376629Notes

Reaction equation

HRID 2376629 reaction equation
[OH-].[Na+:2].C([O:5][C:6]([CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]3[C:21](=[C:22]([C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=4)[N:23]=2)[N:20]=[CH:19][CH:18]=[CH:17]3)[CH2:10][CH2:9]1)=[O:7])C.O.C(OCC)(=O)C>C1COCC1>[F:30][C:26]1[CH:25]=[C:24]([C:22]2[N:23]=[C:14]([N:11]3[CH2:12][CH2:13][CH:8]([C:6]([O-:7])=[O:5])[CH2:9][CH2:10]3)[CH:15]=[C:16]3[C:21]=2[N:20]=[CH:19][CH:18]=[CH:17]3)[CH:29]=[CH:28][CH:27]=1.[Na+:2]

Participants

6

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 10385049HCID 10385049, compound

Product 1

HCID 23688043HCID 23688043, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydroxide (1 M, 0.25 ml) is added to a solution of 1-[8-(3-fluoro-phenyl)-[1,7]naphthyridin-6-yl]-piperidine-4-carboxylic acid ethyl ester (96 mg, 0.25 mmol) in THF (1 ml). The solution is stirred at room temperature for 24 hours, then heated to 45° C. for 24 hours. Water and ethyl acetate are added and the aqueous phase separated and evaporated to give the title compound. MS: APCI 352.0 MH+.

Workup

  1. temperatureheated to 45° C. for 24 hours
  2. customthe aqueous phase separated
  3. customevaporated

Sources & evidence

ORD record
ord-e964652bcdb74f8181dfbddd6edd7e26
Source dataset
uspto-grants-2008_12
Patent number
US07468370B2

Reaction notes

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