Isonicotinic Acid → Isonicotinoyl chloride hydrochloride

HRID 2376786Notes

Reaction equation

[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.S(Cl)([Cl:12])=O>>[ClH:12].[C:1]([Cl:12])(=[O:9])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 5922Isonicotinic Acid

HCID 24386Thionyl Chloride

Product 1

HCID 12262826Isonicotinoyl chloride hydrochloride

Procedure

A solution of isonicotinic acid (0.10 g, 0.8 mmol) and thionyl chloride (1 mL) were heated to reflux for 2 h and concentrated. The product obtained was used immediately in the following step.

Workup

temperatureto reflux for 2 h
concentrationconcentrated
customThe product obtained

Sources & evidence

ORD record: ord-5ebf3a2ea9b54de4b354cc2512b07ac4
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07468376B2

Reaction notes

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