Dimethylformamide dimethyl acetal → HCID 86602114, compound

HRID 2377047Notes

Reaction equation

HRID 2377047 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>CN(C=O)C>[CH3:18][N:19]([CH3:21])/[CH:20]=[CH:1]/[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 44549262HCID 44549262, compound

Product 1

HCID 86602114HCID 86602114, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of ethyl 4-methyl-5-nitropyridine-2-carboxylate (39.5 g, 0.19 mol), dimethylformamide-dimethylacetal (DMF-DMA) (30.6 g, 0.26 mol, 1.35 eq) in DMF (470 mL) was heated to 90° C. for 30 min. The solvent was removed in vacuo. The residue (78 g) was used without further purification in the next step.

Workup

  1. customThe solvent was removed in vacuo
  2. customThe residue (78 g) was used without further purification in the next step

Sources & evidence

ORD record
ord-b4dc6674623440ea8dd4409b12dd4645
Source dataset
uspto-grants-2008_12
Patent number
US07468375B2

Reaction notes

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