4-Methylmorpholine → HCID 15957086, compound

HRID 2377116Notes

Reaction equation

HRID 2377116 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][N:13]=[C:14]([C:17](O)=[O:18])[CH:15]=2)[N:10]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH:9]=1)[CH3:2].ClC1N=C(OC)N=C(OC)N=1.CN1CCOCC1.Cl.[CH3:47][O:48][NH2:49]>>[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][N:13]=[C:14]([C:17]([NH:49][O:48][CH3:47])=[O:18])[CH:15]=2)[N:10]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=2)[CH:9]=1)[CH3:2]

Participants

5

Reactant 4

HCID 79724-MethylmorpholineHCID 184502-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 59855820HCID 59855820, compound

Product 1

HCID 15957086HCID 15957086, compound

Procedure

The title compound was prepared as in example 116, step 3, using 3-[(2-ethoxyethoxy)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid, 2-chloro-4,6-dimethoxy-1,3,5-triazine, N-methyl morpholine, and O-methyl hydroxylamine hydrochloride. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.07 (t, J=6.95 Hz, 3H) 3.40 (q, J=6.99 Hz, 2H) 3.47-3.51 (m, 2H) 3.53-3.57 (m, 2H) 3.68 (s, 3H) 4.67 (s, 2H) 5.56 (s, 2H) 7.16 (t, J=8.97 Hz, 2H) 7.31-7.40 (m, 2H) 7.83 (s, 1H) 8.26 (s, 1H) 8.84 (s, 1H) 11.73 (s, 1H)

Sources & evidence

ORD record
ord-a26cef411cc247cebe1d28b7206a0e3e
Source dataset
uspto-grants-2008_12
Patent number
US07468375B2

Reaction notes

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