反应详情

温度

50 °C

8.0 g (0.036 M) of methyl 6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate and 15.0 g (0.108 M) of potassium carbonate are introduced into 80 ml of DMF. The reaction mixture is stirred for 1 hour at 50° C. After addition of 3.0 ml (0.037 M) of iodoethane and heating for 12 hours at 50° C., the reaction medium is poured into 400 ml of demineralized water. A brown solid precipitates out. The solid is filtered off, washed thoroughly with water and then with isopropyl ether, and finally dried under vacuum at 40° C.

1. temperatureheating for 12 hours at 50° C.
2. customA brown solid precipitates out
3. filtrationThe solid is filtered off
4. washwashed thoroughly with water
5. dry with materialwith isopropyl ether, and finally dried under vacuum at 40° C.