Hydrochloric Acid → HCID 68892645, compound

HRID 2378950Notes

Reaction equation

HRID 2378950 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[C:9]1=[O:26].[ClH:27].C(OCC)C>C(OCC)(=O)C>[ClH:27].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[C:9]1=[O:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59006355HCID 59006355, compound

Product 1

HCID 68892645HCID 68892645, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 4-(3-(2-fluorophenyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate (235 mg, 0.647 mmol) was dissolved in ethyl acetate (3.0 mL). 2N Hydrogen chloride in diethyl ether (5.0 mL, 10.00 mmol) was added to the mixture. Reaction stirred at room temperature for 22 hours. Solids were filtered off, washed with diethyl ether and then dried in vacuo. Title compound was obtained as white solid in 52% yield. MS (M+H)+=264.1.

Workup

  1. customReaction
  2. filtrationSolids were filtered off
  3. washwashed with diethyl ether
  4. customdried in vacuo

Sources & evidence

ORD record
ord-d85c45f143e54253926d906740b27baf
Source dataset
uspto-grants-2008_12
Patent number
US07470680B2

Reaction notes

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