Iodoethane → 5-Ethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
Reaction equation
[C:1]1(=[O:14])[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[NH:6][C:5]=2[CH2:4][CH2:3][NH:2]1.[H-].[Na+].[CH2:17](I)[CH3:18]>>[CH2:17]([N:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[C:13]2[C:1](=[O:14])[NH:2][CH2:3][CH2:4][C:5]1=2)[CH3:18]Participants
4
Procedure
2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indol-1-one (931 mg) was treated with sodium hydride (60% dispersion in oil; 400 mg) and was then stirred with ethyl iodide (10% v/v solution in DMF; 4 ml) to give the title compound (758 mg), m.p. 203°-204.5°.
Sources & evidence
- ORD record
- ord-38485fcaeda3405eb00f49869b73ef45
- Source dataset
- uspto-grants-1994_11
- Patent number
- US05360800
Reaction notes
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