反应详情

A solution of 10.4 g (61.7 mmoles) of L-phenylalanine in 150 ml of 2N aqueous hydrochloric acid was subjected to a medium pressure catalytic hydrogenation reaction in the presence of 1 g of platinum black using a Paar's apparatus under about 4 atmospheres of hydrogen at room temperature for 24 hours. At the end of this time, the precipitated crystalline substance was dissolved by adding 250 ml of water, and the catalyst was removed by filtration. The filtrate was then concentrated to about 150 ml by evaporation under reduced pressure and allowed to stand overnight. The crystalline substance which deposited was collected by filtration and dried to give 12.8 g (yield 91%) of the title compound as white crystals, melting at 232°-234° C.

1. dissolutionAt the end of this time, the precipitated crystalline substance was dissolved
2. customthe catalyst was removed by filtration
3. concentrationThe filtrate was then concentrated to about 150 ml by evaporation under reduced pressure
4. filtrationThe crystalline substance which deposited was collected by filtration
5. customdried