Hydrazine hydrate (1:1) → 2-Hydrazinyl-5-phenyl-1,3,4-thiadiazole

HRID 2380757Notes

Reaction equation

HRID 2380757 reaction equation
Cl[C:2]1[S:3][C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:5][N:6]=1.O.[NH2:14][NH2:15]>CC(O)C>[C:7]1([C:4]2[S:3][C:2]([NH:14][NH2:15])=[N:6][N:5]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2531452-Chloro-5-phenyl-1,3,4-thiadiazole

Product 1

HCID 2531482-Hydrazinyl-5-phenyl-1,3,4-thiadiazole

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of the 2-Chloro-5-phenyl-[1,3,4]thiadiazole (2 mmol) and hydrazine hydrate (6 mmol, 3 eq) in iPrOH (10 mL) was heated at reflux overnight. The solvent was evaporated, water was added, and the product was isolated by filtration (110 mg, 57%).

Workup

  1. temperatureat reflux overnight
  2. customThe solvent was evaporated
  3. additionwater was added
  4. customthe product was isolated by filtration (110 mg, 57%)

Sources & evidence

ORD record
ord-d89b84f4032c47d3acc9c588e3c7b024
Source dataset
uspto-grants-2012_09
Patent number
US08257931B2

Reaction notes

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