Diisopropylamine → 3-chloro-2-((diphenylmethylene)amino)pyridin-4(1H)-one

Temperature

0 °C

To a 4-L CHEMGLASS® reactor (fitted with addition funnel, nitrogen blanket) was added: crude 3-chloro-N-(diphenylmethylene)pyridin-2-amine and triisopropyl borate (196.38 mL, 852 mmol). The resulting solution was the cooled to 0° C. In a separate reactor was added diisopropylamine (169.78 mL, 1207 mmol) and THF (1.05 L). This solution was cooled to 0° C. and n-butyl lithium (683.22 mL, 923 mmol) was added slowly. After stirring at 0° C., this solution was added slowly to the first solution. The reaction mixture was stirred for 30 min without the cooling bath (HPLC indicated consumption of starting material). Water (1.05 L) was added to the mixture, followed by the addition of sodium percarbonate (336.34 g, 1065 mmol) in one portion. This mixture was allowed to stir at 20° C. for 1 h. A saturated solution of NaHSO3 (˜1 L) was added slowly. The aqueous layer was removed and DMF (840.00 mL) was added to the organic layer and the THF was distilled off (solvent swap from THF to DMF). The DMF was used without further purification. 1H NMR (CDCl3) δ 6.02 (d, 1H, J=7.1 Hz), 7.10 (d, 1H, J=7.1 Hz), 7.20-7.80 (m, 10H); MS (ESI+) m/z 309.07 (M+H)+.

1. additionwas added
2. temperatureThis solution was cooled to 0° C.
3. additionthis solution was added slowly to the first solution
4. stirringThe reaction mixture was stirred for 30 min without the cooling bath (HPLC indicated consumption of starting material)
5. stirringto stir at 20° C. for 1 h
6. customThe aqueous layer was removed
7. additionDMF (840.00 mL) was added to the organic layer
8. distillationthe THF was distilled off (solvent swap from THF to DMF)
9. customThe DMF was used without further purification

ORD record

ord-602475a596ab4b63aba05aa40404830c

Source dataset

uspto-grants-2012_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08258118B2