Perchloric Acid → HCID 24854990, compound

HRID 2381051Notes

Reaction equation

HRID 2381051 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N:3]=1.[Cl:9][C:10]1[C:11]([CH:21]=O)=[C:12]([CH:18]=[CH:19][CH:20]=1)[O:13][CH2:14][C:15]([NH2:17])=[O:16].[CH3:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[C:25]=1[N+:31]#[C-:32].Cl(O)(=O)(=O)=O>C(O)C>[NH2:17][C:15]([CH2:14][O:13][C:12]1[CH:18]=[CH:19][CH:20]=[C:10]([Cl:9])[C:11]=1[C:21]1[N:1]=[C:2]2[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N:3]2[C:32]=1[NH:31][C:25]1[C:26]([CH3:30])=[CH:27][CH:28]=[CH:29][C:24]=1[CH3:23])=[O:16]

Participants

6

Reactant 4

HCID 24247Perchloric AcidHCID 760092,6-Dimethylphenyl isocyanideHCID 27377012-Amino-5-fluoropyridineHCID 58387824HCID 58387824, compound

Product 1

HCID 24854990HCID 24854990, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.2 0.177 g of 2-amino-5-fluoropyridine 4 and 0.288 g of the aldehyde 10 are dissolved successively in 30 ml of ethanol at RT under an inert gas. 0.205 g of 2,6-dimethylphenylisocyanide 5 is then added, 64.1 μl of 70% perchloric acid are added dropwise, and the mixture is stirred at RT for a further 20 h. The mixture is subsequently subjected to conventional work-up, giving 0.286 g (43%) of “A3”; m.p. 186-187°; MS-EI (M+)=438.

Sources & evidence

ORD record
ord-55f72b0474274c508bc6175f1a2d336c
Source dataset
uspto-grants-2012_09
Patent number
US08258151B2

Reaction notes

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