反应详情

Prepared according to the procedure described in Example 36, above. Hydroxy β-lactone 13f (10 mg, 0.033 mmol), N-formylglycine (12.0 mg, 0.120 mmol), triphenylphosphine (26.6 mg, 0.099 mmol), and 0.5 mL of xylene were combined and the mixture was azeotroped in vacuo for 1.0 h. THF (1.4 mL) was then added followed by DIAD (21.0 μL, 0.108 mmol). After 12 hours the mixture was concentrated in vacuo, and purified by chromatography (SiO2, 10 to 30% EtOAc:hexanes) to afford β-lactone 15i (5.5 mg, 43%).

1. customPrepared
2. customthe mixture was azeotroped in vacuo for 1.0 h
3. additionTHF (1.4 mL) was then added
4. concentrationAfter 12 hours the mixture was concentrated in vacuo
5. custompurified by chromatography (SiO2, 10 to 30% EtOAc:hexanes)