HRID2382326

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID73888

Butanoic acid, 4-chloro-4-oxo-, methyl ester

C5H7ClO3

HCID81531

Diisopropylethylamine

C8H19N

结构：CC(=O)N1c2ccc(NC(=O)c3ccccc3O)cc2C(C)(c2ccccc2)CC1(C)C

HCID17962902

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCC(=O)Oc1ccccc1C(=O)Nc1ccc2c(c1)C(C)(c1ccccc1)CC(C)(C)N2C(C)=O

HCID17962912

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Acylation of 1-acetyl-6-(2-hydroxybenzoyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (20 mg) with 3-carbomethoxypropionyl chloride (14 mg) and N,N-diisopropylethylamine (40 μl) in tetrahydrofuran (2 ml) was performed according to the method described in example 6.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf16aab756d743dbb5ba3d4096e555e3
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08258293B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:15](=[O:23])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[OH:22])=[CH:11][CH:12]=2)[C:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([CH3:24])[CH2:6][C:5]1([CH3:32])[CH3:31])(=[O:3])[CH3:2].[C:33]([CH2:37][CH2:38][C:39](Cl)=[O:40])([O:35][CH3:36])=[O:34].C(N(CC)C(C)C)(C)C>O1CCCC1>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:15](=[O:23])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][C:39]([CH2:38][CH2:37][C:33]([O:35][CH3:36])=[O:34])=[O:40])=[CH:11][CH:12]=2)[C:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([CH3:24])[CH2:6][C:5]1([CH3:32])[CH3:31])(=[O:3])[CH3:2]