Lithium hydroxide, monohydrate → HCID 45381833, compound

HRID 2383348Notes

Reaction equation

HRID 2383348 reaction equation
C[O:2][C:3]([C:5]1[O:9][C:8]([C:10]2[CH:19]=[C:18]([C:20]#[N:21])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=2)=[N:7][C:6]=1[CH3:22])=[O:4].O.[OH-].[Li+]>O1CCCC1.C(O)C.O>[C:20]([C:18]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:8]2[O:9][C:5]([C:3]([OH:4])=[O:2])=[C:6]([CH3:22])[N:7]=2)[CH:19]=1)#[N:21]

Participants

6

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 67309601HCID 67309601, compound

Product 1

HCID 45381833HCID 45381833, compoundYield 65.4%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

To a mixed solution of 2-(4-cyanonaphthalene-2-yl)-4-methyloxazole-5-carboxylic acid methyl ester (0.045 g) in tetrahydrofuran (1.5 mL), ethanol (0.8 mL) and water (0.8 mL) was added lithium hydroxide monohydrate (0.02 g), and the mixture was stirred for 30 minutes. To the reaction solution was added water, and the resulting mixture was washed with diethyl ether. To the aqueous layer was added 1 mol/L hydrochloric acid (0.5 mL). The precipitated solid was collected by filtration, and dried under reduced pressure to give the title compound (0.028 g).

Workup

  1. washthe resulting mixture was washed with diethyl ether
  2. additionTo the aqueous layer was added 1 mol/L hydrochloric acid (0.5 mL)
  3. filtrationThe precipitated solid was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-357d173cb6f24bfe8ae5d0449415fe1a
Source dataset
uspto-grants-2012_09
Patent number
US08263622B2

Reaction notes

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