Hydrochloric Acid → HCID 178481021, compound

HRID 2384540Notes

Reaction equation

HRID 2384540 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][CH2:9][C:10]([N:12]([CH2:14][CH:15](OC)OC)[CH3:13])=[O:11])[CH2:4][CH2:3]1.Cl.[H][H]>[Pt].CO.O>[OH:1][C@H:2]1[CH2:3][CH2:4][C@H:5]([N:8]2[CH2:15][CH2:14][N:12]([CH3:13])[C:10](=[O:11])[CH2:9]2)[CH2:6][CH2:7]1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 178418361HCID 178418361, compoundHCID 178495939HCID 178495939, compound

Product 1

HCID 178481021HCID 178481021, compound

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

82 g platinum on charcoal (5%) are added to a solution of 822 g (trans)-1-hydroxy-4-{[N-(2,2-dimethoxy-ethyl)-N-methyl-amino]-carbonylmethylamino}-cyclohexane in 4500 ml of methanol and 450 ml of water. After the addition of 499 ml concentrated hydrochloric acid hydrogenation with hydrogen is begun immediately. During the hydrogenation process the mixture is heated to 50° C. After 3 h it is filtered.

Workup

  1. filtrationAfter 3 h it is filtered

Sources & evidence

ORD record
ord-59b066e355154c20b553187f4f13434b
Source dataset
uspto-grants-2012_09
Patent number
US08263768B2

Reaction notes

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