反应详情

Dissolve 4-bromo-2-methoxy-phenol (1.032 g, 5.08 mmol) in CH2Cl2 (10 mL), and treat with TsCl (0.969 g, 5.08 mmol) followed by Et3N (1.06 mL, 7.62 mmol). Stir the reaction at RT for 2 h. Dilute with EtOAc (100 mL) and wash with water (2×30 mL). Dry with Na2SO4, filter, and concentrate to give 1.81 g (100%) of the title compound. MS/ES m/z (81Br) 380.9 [M+Na]+.

1. customthe reaction at RT for 2 h
2. washwash with water (2×30 mL)
3. dry with materialDry with Na2SO4
4. filtrationfilter
5. concentrationconcentrate