Dimethylformamide dimethyl acetal → HCID 178517519, compound

HRID 2385567Notes

Reaction equation

HRID 2385567 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]3([C:29]4[C:20](=[CH:21][C:22]5[O:27][CH2:26][CH2:25][O:24][C:23]=5[CH:28]=4)[O:19][CH2:18]3)[C:10]2=[O:30])=[CH:4][CH:3]=1.COC(OC)[N:34]([CH3:36])C.Cl.N[OH:41]>CC(O)C>[OH:41][N:34]=[CH:36][NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]3([C:29]4[C:20](=[CH:21][C:22]5[O:27][CH2:26][CH2:25][O:24][C:23]=5[CH:28]=4)[O:19][CH2:18]3)[C:10]2=[O:30])=[CH:6][N:7]=1

Participants

5

Reactant 3

HCID 78373Dimethylformamide dimethyl acetal2×HCID 443297Hydroxyamine hydrochlorideHCID 59352362HCID 59352362, compound

Product 1

HCID 178517519HCID 178517519, compoundYield 83.3%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 1′-[(6-aminopyridin-3-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3′-indol]-2′(1′H)-one (0.40 g, 1.0 mmol) in 2-propanol was added N,N-dimethylformamide dimethyl acetal (0.17 mL, 1.3 mmol). The mixture was heated at reflux for 3 h, allowed to cool to ambient temperature and further N,N-dimethylformamide dimethyl acetal (0.12 mL, 0.9 mmol) was added. The mixture was heated at reflux for 6 h and allowed to cool to 50° C. Hydroxylamine hydrochloride (0.15 g, 2.2 mmol) was added and the mixture was stirred at 50° C. for 16 h. The mixture was allowed to cool to ambient temperature, during which time a precipitate was deposited. The solid was filtered, washed with 2-propanol and diethyl ether and dried to afford N′-hydroxy-N-{5-[(2′-oxo-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3′-indol]-1′(2′H)-yl)methyl]pyridin-2-yl}imidoformamide (0.37 g, 82%) as a colorless solid: mp 231-232° C.; 1H NMR (300 MHz, DMSO-d6) δ10.07 (s, 1H), 9.41-9.35 (m, 1H), 8.23-8.19 (m, 1H), 7.84-7.78 (m, 1H), 7.59-7.53 (m, 1H), 7.32-7.24 (m, 1H), 7.19-7.13 (m, 1H), 7.13-7.07 (m, 1H), 7.07-6.99 (m, 2H), 6.52 (s, 1H), 6.05 (s, 1H), 4.86-4.83 (m, 2H), 4.73 (ABq, J=44.3, 9.4 Hz, 2H), 4.22-4.06 (m, 4H); 13C NMR (75 MHz, DMSO-d6) δ 176.7, 154.6, 152.0, 146.6, 144.1, 141.8, 137.7, 137.5, 135.4, 131.7, 128.7, 124.0, 123.6, 123.0, 121.1, 110.8, 110.4, 109.4, 98.8, 79.3, 64.1, 63.5, 57.2; MS (ES+) m/z 444.9 (M+1).

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 3 h
  3. temperatureThe mixture was heated
  4. temperatureat reflux for 6 h
  5. temperatureto cool to 50° C
  6. temperatureto cool to ambient temperature, during which time a precipitate
  7. filtrationThe solid was filtered
  8. washwashed with 2-propanol and diethyl ether
  9. customdried

Sources & evidence

ORD record
ord-e86fbff9d7ed47c788599fb1f8a71a0c
Source dataset
uspto-grants-2012_09
Patent number
US08263606B2

Reaction notes

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