2-Bromo-4-nitrophenol → 4-Amino-2-bromophenol

HRID 2386964Notes

Reaction equation

HRID 2386964 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[OH:11].[Cl-].[NH4+]>[Fe].CO>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([OH:11])=[C:2]([Br:1])[CH:7]=1

Participants

5

Reactant 2

HCID 221092-Bromo-4-nitrophenol2×HCID 25517Ammonium Chloride

Product 1

HCID 144402654-Amino-2-bromophenol

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 887MethanolSolvent

Procedure

The target compound was obtained by reducing 2-bromo-4-nitrophenol with iron in a mixed solution of methanol and ammonium chloride aqueous solution. 2-bromo-4-nitrophenol was manufactured by the method described in the literature (J. Org. Chem., Vol. 62, 1997, p. 4504).

Workup

  1. customThe target compound was obtained

Sources & evidence

ORD record
ord-5a4a848ad6ad4a9bb141bd1e26fb4728
Source dataset
uspto-grants-2012_09
Patent number
US08268842B2

Reaction notes

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