Hydrochloric Acid → HCID 68505044, compound

HRID 2387237Notes

Reaction equation

HRID 2387237 reaction equation
[CH3:1][CH:2]1[N:7]([C@H:8]2[CH2:12][CH2:11][O:10][CH2:9]2)[C:6](=[O:13])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:21]>CCOC(C)=O.O1CCOCC1>[ClH:21].[CH3:1][CH:2]1[N:7]([C@H:8]2[CH2:12][CH2:11][O:10][CH2:9]2)[C:6](=[O:13])[CH2:5][NH:4][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86761616HCID 86761616, compound

Product 1

HCID 68505044HCID 68505044, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

Crude II2 was dissolved in EtOAc, then 4M HCl in dioxane was added. The mixture was stirred at RT for 30 min. After the removal of the solvent under reduced pressure, the crude was scratched with Et2O and the solvent decanted to afford the title compound (II3). MS (ES) C9H17ClN2O2 requires: 184, found: 185 (M+H)+.

Workup

  1. customAfter the removal of the solvent under reduced pressure
  2. customthe solvent decanted

Sources & evidence

ORD record
ord-a56ff2b2e1ff4305961edd781df821e1
Source dataset
uspto-grants-2012_09
Patent number
US08268827B2

Reaction notes

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