反应详情

To a solution of ethyl [3-(3-iodopropyl)phenoxy]acetate (2.5 g) in DMF (50 mL) was added (3,3-diphenylpropyl)amine (1.7 g) at ambient temperature. The reaction mixture was stirred for 8 hours at the same temperature. The resulting mixture was diluted with EtOAc and washed successively with saturated NaHCO3 aqueous solution, water and brine. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0-95:5) to give ethyl (3-{3-[(3,3-diphenylpropyl)amino]propyl}phenoxy)acetate (1.25 g).

1. washwashed successively with saturated NaHCO3 aqueous solution, water and brine
2. dry with materialThe organic layer was dried over anhydrous MgSO4
3. filtrationfiltered
4. customevaporated in vacuo
5. customThe residue was purified by silica gel column chromatography (chloroform:MeOH=100:0-95:5)