Hydrochloric Acid → HCID 42614143, compound

HRID 2389536Notes

Reaction equation

HRID 2389536 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]([NH:11]C(=O)OC(C)(C)C)[CH2:2]1.[ClH:19]>C(OCC)(=O)C.O1CCOCC1>[ClH:19].[ClH:19].[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]([NH2:11])[CH2:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 4460996Boc-3-amino-1,2,3,4-tetrahydroquinoline

Product 1

HCID 42614143HCID 42614143, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

To a stirred room temperature solution of tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate (1.0 g) in ethyl acetate (20 mL) was added 4 M HCl in dioxane (10 mL). After 6 hours the mixture was evaporated to dryness to obtain 1,2,3,4-tetrahydroquinolin-3-amine bis HCl salt as a cream colored solid (925 mg).

Workup

  1. customAfter 6 hours the mixture was evaporated to dryness

Sources & evidence

ORD record
ord-f5d16909f23f49f2994403194b6e4c0c
Source dataset
uspto-grants-2012_09
Patent number
US08273754B2

Reaction notes

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