反应详情

Lithium hydroxide (2.8 g, 120.25 mmol) was added to a stirred mixture of ethyl 2-tert-butylthiazole-4-carboxylate (6.56 g, 30.76 mmol) in THF (100 mL) and water (40 mL). After 16 h, HCl (62.5 mL, 125 mmol) was added and the solution concentrated to ˜40 mL. The reaction mixture was partitioned between EtOAc and brine. The aqueous layer was extracted with EtOAc (×3). The combined organic layers were dried over magnesium sulphate, filtered and evaporated in vacuo to give the sub-title compound as an off white/yellow solid. Yield: 5.41 g

1. concentrationthe solution concentrated to ˜40 mL
2. customThe reaction mixture was partitioned between EtOAc and brine
3. extractionThe aqueous layer was extracted with EtOAc (×3)
4. dry with materialThe combined organic layers were dried over magnesium sulphate
5. filtrationfiltered
6. customevaporated in vacuo