Potassium Carbonate → HCID 68766282, compound

HRID 2391702Notes

Reaction equation

HRID 2391702 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[OH:14][C:15]1[CH:19]=[C:18]([N:20]2[C:24]3[CH:25]=[N:26][CH:27]=[CH:28][C:23]=3[N:22]=[CH:21]2)[S:17][C:16]=1[C:29]([O:31][CH3:32])=[O:30].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][O:14][C:15]2[CH:19]=[C:18]([N:20]3[C:24]4[CH:25]=[N:26][CH:27]=[CH:28][C:23]=4[N:22]=[CH:21]3)[S:17][C:16]=2[C:29]([O:31][CH3:32])=[O:30])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27375764-Fluoro-2-(trifluoromethyl)benzyl bromideHCID 68765327methyl 3-hydroxy-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate

Product 1

HCID 68766282HCID 68766282, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner as described for example B11, 110.5 mg of 4-fluoro-2-(trifluoromethyl)benzyl bromide, 100 mg of methyl 3-hydroxy-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate, 59.7 mg of potassium carbonate in 3 ml anhydrous DMF yield the title compound.

Sources & evidence

ORD record
ord-61dd36b9e5834cf4ac90397d6f4fbd87
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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