Hydrochloric Acid → HCID 18974714, compound

HRID 2393235Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:6]=[C:7]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=2)=[O:17])[CH:8]=[C:9]([C:11]([O:13]C)=[O:12])[CH:10]=1)=[O:4].[OH-].[Na+].Cl.NC(N)=O>>[C:3]([C:5]1[CH:6]=[C:7]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=2)=[O:17])[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[CH:10]=1)([OH:4])=[O:2]

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 1176Urea

HCID 14798Sodium Hydroxide

HCID 2954358HCID 2954358, compound

Product 1

HCID 18974714HCID 18974714, compoundYield 91%

Procedure

The urea (7.67) (100 mg, 0.27 mmol) was added to a stirred solution of sodium hydroxide (1M, 5 ml). After 0.5 h the reaction was complete by TLC examination. The reaction mixture was neutralised to pH 2 with 1M HCl, causing the urea to precipitate. The precipitate was collected by filtration, washed, dried, and recrystallised from dioxan to give the title compound 7.65 as a yellow powder (82 mg, 91%).

Workup

customto precipitate
filtrationThe precipitate was collected by filtration
washwashed
customdried
customrecrystallised from dioxan

Sources & evidence

ORD record: ord-c7365da66f5c4dee9eedb534f922d757
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05807688

Reaction notes

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