Dimethyl Disulfide → HCID 70104303, compound

HRID 2393569Notes

Reaction equation

HRID 2393569 reaction equation
[CH2:1]([S:4][C:5]1[N:6]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:19])([CH3:18])[CH3:17])[C:7](Br)=[C:8]([Br:10])[N:9]=1)[CH2:2][CH3:3].CC[Mg+].[Br-].[CH3:24][S:25]SC.[NH4+].[Cl-]>C1COCC1.CCOCC.CCOC(C)=O>[CH2:1]([S:4][C:5]1[N:6]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:19])([CH3:18])[CH3:17])[C:7]([S:25][CH3:24])=[C:8]([Br:10])[N:9]=1)[CH2:2][CH3:3]

Participants

8

Reactant 4

HCID 12232Dimethyl DisulfideHCID 25517Ammonium ChlorideHCID 70105092HCID 70105092, compoundHCID 178461630HCID 178461630, compound

Product 1

HCID 70104303HCID 70104303, compound

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

2.4 g of the expected product from Stage B is dissolved in 25 cm3 of anhydrous THF. 3 ml of a 3M solution of EtMgBr in ether is added. After 1 hour at ambient temperature, 1.08 cm3 of dimethyl disulphide is added and the reaction medium is left for 1 hour at ambient temperature followed by hydrolysis with saturated NH4Cl, extraction with AcOEt, drying and evaporating to dryness.

Workup

  1. waitthe reaction medium is left for 1 hour at ambient temperature
  2. customdrying
  3. customevaporating to dryness

Sources & evidence

ORD record
ord-c7a985f3e35e473483812ec28ea426dd
Source dataset
uspto-grants-1998_09
Patent number
US05807878

Reaction notes

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