Benzaldehyde → HCID 54713212, compound

HRID 2394032Notes

Reaction equation

HRID 2394032 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)=[C:10]([CH3:22])[CH:9]=2)[O:5][C:4](=[O:23])[CH:3]=1.[CH:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[CH:32]1([SH:38])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1.N1CCCCC1.[K+].[Br-]>C(O)(=O)C>[CH:32]1([S:38][CH:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:3]2[C:4](=[O:23])[O:5][C:6]([C:8]3[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]4[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=4)=[C:10]([CH3:22])[CH:9]=3)=[CH:7][C:2]=2[OH:1])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

7

Reactant 5

HCID 240BenzaldehydeHCID 8082PiperidineHCID 15290CyclohexanethiolHCID 253877Potassium BromideHCID 54681365HCID 54681365, compound

Product 1

HCID 54713212HCID 54713212, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared by Method C using 4-hydroxy-6-[3-methyl-4-(3-pyridinylmethoxy)phenyl]-2H-pyran-2-one (0.5 g, 1.62 mmol), benzaldehyde (0.189 g, 1.78 mmol), cyclohexylmercaptan (0.489 g, 4.212 mmol), piperidine, (0.5 mL), acetic acid (0.5 mL). m.p. 84°-87° C. (d); IR (KBr) 3059, 2930, 2853, 1676, 1601, 1449, 1260, 1134, 700 cm-1 ; MS (CI) m/e 446 (2), 331 (9), 226 (61), 205 (24), 135 (44).

Sources & evidence

ORD record
ord-a090e33ac86e427fb2bf330792ca8531
Source dataset
uspto-grants-1998_09
Patent number
US05808062

Reaction notes

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