Oxalyl chloride → HCID 10846987, compound

HRID 2394282Notes

Reaction equation

HRID 2394282 reaction equation
[F:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([OH:14])=O)=[CH:4][N:3]=1.C(Cl)(=O)C([Cl:18])=O>CN(C=O)C.ClCl>[F:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([Cl:18])=[O:14])=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 10703627HCID 10703627, compound

Product 1

HCID 10846987HCID 10846987, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 24526ChlorineSolvent

Procedure

The title compound was prepared as described in Example 25, but employing a solution of 2-fluoro-4-trifluoromethylpyrimidine-5-carboxylic acid (1.5 g, 7.1 mmol) and oxalyl chloride (1.0 g, 8 mmol), DMF (2 drops) in CH2 Cl2 (30 mL) resulted in a 75% yield (1.2 g); 1H NMR (CDCl3) δ 9.42 (s, 1H).

Workup

  1. customresulted in a 75% yield (1.2 g)

Sources & evidence

ORD record
ord-dbae4f97a355460c88eedd0b8243546a
Source dataset
uspto-grants-1998_09
Patent number
US05811428

Reaction notes

Loading…