Hydrochloric Acid → HCID 70042532, compound

HRID 2396142Notes

Reaction equation

HRID 2396142 reaction equation
[CH2:1]([O:8][C:9](=[O:34])[C@H:10]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[NH:11][C:12]([N:14]([CH2:16][CH2:17][N:18](C(OC(C)(C)C)=O)[CH3:19])[CH3:15])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:35]>C(OCC)(=O)C>[ClH:35].[CH2:1]([O:8][C:9](=[O:34])[C@H:10]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[NH:11][C:12]([N:14]([CH2:16][CH2:17][NH:18][CH3:19])[CH3:15])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22858686HCID 22858686, compound

Product 1

HCID 70042532HCID 70042532, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-[N-[2-(N-tert-Butoxycarbonyl-N-methylamino)ethyl]-N-methylaminocarbonyl]-L-phenylalanine benzyl ester (11 g was dissolved in a solution of 4M hydrogen chloride in ethyl acetate (200 ml) under ice-bath cooling. After being stirred at the same temperature for 30 minutes, the solution was concentrated in vacuo to give N-[N-[2-(N-methylamino)ethyl]-N-methylaminocarbonyl]-L-phenylalanine benzyl ester hydrochloride (10 g) as an oil.

Workup

  1. temperaturecooling
  2. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-1a2b3f4b29c94b819b219ee4635205a3
Source dataset
uspto-grants-1996_02
Patent number
US05491132

Reaction notes

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