Hydrochloric Acid → N-thiomorpholinocarbonyl-N,N'-dimethylethylenediamine hydrochloride

HRID 2396148Notes

Reaction equation

HRID 2396148 reaction equation
C(O[C:6]([N:8](C)[CH2:9][CH2:10][N:11]([C:13]([N:15]1[CH2:20][CH2:19][S:18][CH2:17][CH2:16]1)=[O:14])[CH3:12])=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[S:18]1[CH2:19][CH2:20][N:15]([C:13]([N:11]([CH3:12])[CH2:10][CH2:9][NH:8][CH3:6])=[O:14])[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18988036N-t-butoxycarbonyl-N'-thiomorpholinocarbonyl-N,N'-dimethylethylenediamine

Product 1

HCID 18988040N-thiomorpholinocarbonyl-N,N'-dimethylethylenediamine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-t-Butoxycarbonyl-N'-thiomorpholinocarbonyl-N,N'-dimethylethylenediamine (4.92 g) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (60 ml) under ice-bath cooling. After being stirred at ambient temperature for 30 minutes, the solution was concentrated in vacuo to give N-thiomorpholinocarbonyl-N,N'-dimethylethylenediamine hydrochloride (3.93 g) as an oil. Rf: 0.25 (chloroform:methanol:acetic acid, 8:1:1, V/V)

Workup

  1. temperaturecooling
  2. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-76fcb396482947d9a91b1bcbd561fbe9
Source dataset
uspto-grants-1996_02
Patent number
US05491132

Reaction notes

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