反应详情

Dissolve 3-[(phenacyl)benzylamino]-2-carbethoxy-4,6-dichloroindole (0.5 g, 1.07 mmol) in tetrahydrofuran (10 mL) and water (10 mL). Add lithium hydroxide monohydrate (0.16 g, 3.74 mmol) and stir for 24 hours. Heat at reflux for 6 hours and pour into 1N hydrochloric acid (100 mL). Extract into ethyl acetate, dry (MgSO4) and evaporate the solvent in vacuo. Recrystallize (ethyl acetate/hexane) to give the title compound; mp 266°-7° C.

1. temperatureHeat
2. temperatureat reflux for 6 hours
3. extractionExtract into ethyl acetate
4. dry with materialdry (MgSO4)
5. customevaporate the solvent in vacuo
6. customRecrystallize (ethyl acetate/hexane)