Benzaldehyde → (Z)-Benzaldehyde oxime

HRID 2396676Notes

Reaction equation

HRID 2396676 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:10][OH:11].C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1](=[N:10][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 12143(Z)-Benzaldehyde oximeYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10.6 g of benzaldehyde, 7.0 g of hydroxylamine HCl salt and 14.0 g of potassium carbonate were suspended in 200 ml of methanol, and were stirred at room temperature for 5 hours. The reaction mixture was filtered, and the methanol was distilled off under reduced pressure. The residue thus obtained was purified by silica gel column chromatography to obtain 12.0 g of the above identified compound as a white crystal (yield 99%).

Workup

  1. filtrationThe reaction mixture was filtered
  2. distillationthe methanol was distilled off under reduced pressure
  3. customThe residue thus obtained
  4. customwas purified by silica gel column chromatography
  5. customto obtain 12.0 g of the

Sources & evidence

ORD record
ord-e04a53d1e45e44f1bf7a00cebbff18d1
Source dataset
uspto-grants-1996_02
Patent number
US05494888

Reaction notes

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