Perfluoro-1-butanesulfonyl fluoride → 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-

HRID 2397154Notes

Reaction equation

HRID 2397154 reaction equation
COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C.O=S(=O)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F>C1CCC2=NCCCN2CC1.C1CCOC1>COC(=O)[C@@H]1C[C@H](F)CN1C(=O)OC(C)(C)C

Participants

5

Reactant 2

HCID 67814Perfluoro-1-butanesulfonyl fluorideHCID 10752873N-Boc-cis-4-hydroxy-L-proline methyl ester

Product 1

HCID 109777731,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-Yield 59%

Reagents, catalysts & solvents 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 8028TetrahydrofuranSolvent2×

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-e1c475b70bee4cc0adc37dd3eeb4b39e
Source dataset
Deoxyfluorination screen
Original link
View source

Reaction notes

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