HRID2397490

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID5360545

Sodium

HCID13450523

2,4-Dibromobenzoyl chloride

C7H3Br2ClO

结构：COc1ccc2[nH]c(C)c(CCN3CCCCC3CC3CCCCC3)c2c1

HCID21313365

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(c1)c(CCN1CCCCC1CC1CCCCC1)c(C)n2C(=O)c1ccc(Br)cc1Br

HCID21313385

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

1-(2,4-Dibromobenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole is prepared by reaction of 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole with sodium hydride in DMF and reaction of the resulting sodium salt with 2,4-dibromobenzoyl chloride following the procedure described above in Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c56f9ce595c449b9ed98d89a3ac83b0
来源数据集: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04021431
来源说明: uspto-grants-1977_05

反应 SMILES

[CH:1]1([CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][N:9]2[CH2:14][CH2:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=3)[NH:18][C:17]=2[CH3:27])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].[Na].[Br:31][C:32]1[CH:40]=[C:39]([Br:41])[CH:38]=[CH:37][C:33]=1[C:34](Cl)=[O:35]>CN(C=O)C>[Br:31][C:32]1[CH:40]=[C:39]([Br:41])[CH:38]=[CH:37][C:33]=1[C:34]([N:18]1[C:19]2[C:24](=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)[C:16]([CH2:15][CH2:14][N:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH:8]2[CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[C:17]1[CH3:27])=[O:35]