Benzoyl chloride → HCID 21313386, compound

HRID 2397501Notes

Reaction equation

HRID 2397501 reaction equation
[CH:1]1([CH2:7][CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2[CH2:13][CH2:14][C:15]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([O:24][CH3:25])[CH:22]=3)[NH:17][C:16]=2[CH3:26])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].[Na].[C:30](Cl)(=[O:37])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>CN(C=O)C>[C:30]([N:17]1[C:18]2[C:23](=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[C:15]([CH2:14][CH2:13][N:9]2[CH2:10][CH2:11][CH2:12][CH:8]2[CH2:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[C:16]1[CH3:26])(=[O:37])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

6

Reactant 4

HCID 7412Benzoyl chlorideHCID 24758Sodium hydrideHCID 5360545SodiumHCID 21313405HCID 21313405, compound

Product 1

HCID 21313386HCID 21313386, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Reaction of 3-[2-(2-cyclohexylmethylpyrrolidino)ethyl]-5-methoxy-2-methylindole with a mineral oil dispersion of sodium hydride in DMF and reaction of the resulting sodium salt with benzoyl chloride affords 1-benzoyl-3-[2-(2-cyclohexylmethylpyrrolidino)ethyl]-5-methoxy-2-methylindole.

Sources & evidence

ORD record
ord-305a3f952bcd47a7a9c63066b53f70d4
Source dataset
uspto-grants-1977_05
Patent number
US04021431

Reaction notes

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