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HRID2397977

反应详情

EQUATION

反应方程式

HRID 2397977 的结构方程式

REACTANTS

反应物

3
结构：O=S([O-])[O-].[Na+].[Na+]
HCID24437

Sodium sulfite

Na2O3S

结构：CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CCC[C@H](C)[C@]4(CO)[C@H]3CC[C@]12C
HCID70584765

未命名化合物

结构：CC(C)=O.O=S(=O)(O)O.[O]=[Cr](=[O])=[O]
HCID131709961

未命名化合物

PRODUCTS

生成物

1
结构：CCC(=O)O.C[C@H]1CCC=C2CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@]21C=O
HCID86734735

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
40 °C

PROCEDURE

实验过程

To a solution of 1α-methyl-4-androstene-17β,19-diol 17-propionate in dimethylformamide at 40° C. is rapidly added one equivalent of Jones Reagent. The solution is stirred for about 5 hours at 40° C., cooled and a 1% aqueous sodium sulfite solution is added. The precipitate is collected, washed well with water and crystallized from hexane to yield 17β-hydroxy-1α-methyl-4-androsten-19-one propionate.

WORKUP

后处理

  1. customat 40° C.
  2. temperaturecooled
  3. customThe precipitate is collected
  4. washwashed well with water
  5. customcrystallized from hexane